is benzonatate dangerous

Details obtained through investigation by the medical examiner helped to support the possibility of benzonatate over-ingestion in some of our in-house cases. Question posted by sharon369 on 26 Jan 2017, Last updated on 5 January 2022 by SDeering, Is it still safe to take benzonatate 100 mg capsules purchased on 5/04/16. Call your doctor right away if you become pregnant while taking this drug. This medication is sometimes used in dogs for chronic cough. Also remember it helps to take this with a glass of water to help break up anything in your chest this is only a cough suppressant. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. pug? Benzonatate is in a class of medications called antitussives (cough suppressants). The FDA warning focused on accidental overdose in children under 10. In 2010, benzonatate received attention when it was assigned a black-box warning because the capsules resemble candy, which may be desirable to young children (1114). It appeared as a late-eluting compound after trazodone in the base screen and was quantitated by a reference laboratory using traditional HPLC methodology. If children accidentally take benzonatate seek medical attention immediately. Revision date: May 25, 2022. Benzonatate relieves cough by acting directly on the lungs and the breathing passages. Copyright 2022 Scripps Media, Inc. All rights reserved. Its effects last for 38 hours. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Benzonatate is a prescription drug approved for relief of cough in patients over 10 years of age. Keep this drug away from young children. Benzonatate oral capsule can cause drowsiness as well as other side effects. Always speak with your doctor or pharmacist about dosages that are right for you. Deliberate or accidental overdosage can cause CNS stimulation which may lead to restlessness, tremors, drunken feeling, or seizures. All rights reserved. hallucinations (seeing or hearing something that isnt there). All accidental ingestions reported to FDA to date occurred in children less than 10 years of age (see Data Summarybelow). Benzonatate works by numbing the throat and lungs, making the cough reflex less active. Major Pharmaceuticals. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Tell your doctor if your condition lasts or gets worse. Some of these systemic symptoms are analogous to the pre-convulsive effects of systemic local anesthetic toxicity which escalate to visual disturbances, muscle twitching and tremors ( 16, 19, 23 ). It acts peripherally on stretch receptors in the lower respiratory tract to suppress the cough reflex. Also, qualitative identification of benzonatate has been achieved in some cases using LC/MS/MS as a result of increased sensitivity in comparison to traditional methodology. North Carolina Office of the Chief Medical Examiner, Raleigh, NC. It is not to be used for chronic cough that occurs with smoking, asthma, or emphysema or when there is an unusually large amount of mucus or phlegm with the cough. Benzonatate information for Healthcare Professionals. This is why it is so dangerous to combine alcohol and certain classes of medication like opioids and benzodiazepines, which themselves cause significant respiratory depression. Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. information submitted for this request. 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Benzonatate (Tessalon Perles) was approved in 1958 as a peripherally-acting antitussive for its ability to inhibit cough before its mechanism of action was completely understood. Stop taking benzonatate and get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Taking too much Tessalon is dangerous. Even more challenging is the rapid metabolism of the series of n-ethoxy parent compounds without a suitable pure standard available for quantitation of each specific molecular weight. (, Dicpinigaitis, P.V., Gayle, Y.E., Solomon, G., Gibert, R.D. Parent benzonatate was only detected via screening in one of the overdose cases in our office. Signs and symptoms of overdosage include tremors, convulsions, coma, and heart attack. Generally well tolerated if the capsules are swallowed whole. Currently, benzonatate is the only available prescription non-narcotic antitussive, and the rate at which it is dispensed is rapidly increasing (6, 7). Benzonatate comes as a liquid-filled capsule and a capsule to take by mouth. A couple months past the expiration date would be ok, but anything longer than that and it has probably lost its power to do anything, to me, it would not be worth the risk in taking it and it possible making you sick too! Other drugs may interact with benzonatate, including prescription and over-the-counter medicines, vitamins, and herbal products. LFTs require periodic surveillance. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. All rights reserved. Give Light and the People Will Find Their Own Way. Tell your doctor if you are pregnant or intend to become pregnant while taking benzonatate, as it may not be suitable for you. Purchased benzonatate 2/27/16. Disclaimer: Our goal is to provide you with the most relevant and current information. Not recommended during pregnancy; only use if benefits outweigh risks. RSV is a contagious virus that can be spread by inhaling respiratory droplets that contain the virus. Warnings Thats sound advice, but even in adults benzonatate can cause a feeling of numbness in the chest, confusion, and visual hallucinations. You can also get it through contact with, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Tell your doctor about all your current medicines and any medicine you start or stop using. Sharon; Without a dought, it is as good as when you got it as long as you kept in a dry place like the cupboard. Is it still safe to take? Overdosage can be fatal, especially in children. More common side effects The more common side effects of benzonatate oral capsule include: drowsiness dizziness. Important legal mumbo jumbo: Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. The biggest increase was 24% from 2015 to 2016. Taking it again could be fatal (cause death). Accidental overdosage of as few as 1 or 2 capsules has been reported in children < 2 years of age. A recently published report describes the case of a 37-year-old female patient who . Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Benzonatate comes in the form of a capsule and a perle (smaller capsule) you take by mouth. This may cause you to feel dizzy or faint. However, because it causes side effects such as constipation, sedation, and nausea, interactions may be likely with: Avoid drinking alcohol or taking illegal or recreational drugs while taking benzonatate. Common adverse events reported in the overdose cases included cardiac arrest, coma, and convulsion. This medication needs to be swallowed whole. Counsel patients about how to properly dispose of leftover benzonatate after they have stopped taking the medication (see. (, Bhole, M.V., Manson, A.L., Seneviratne, S.L., Misbah, S.A. (, Cohen, V., Jellinek, S.P., Stansfield, L., Truong, H., Baseluos, C., Marshall, J.P. (, Cohan, J.A., Manning, T.J., Lukash, L., Long, C., Ziminski, K.R., Conradi, S.E. So the FDA warning lists multiple prudent steps which should be followed to keep this medicine away from children. Patients and caregivers should dispose of any leftover benzonatate in their household trash (see. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use benzonatate only for the indication prescribed. Im certainly sympathetic to the miserable patient with a cold or bronchitis who has a terrible cough. People in these age groups should not take more than 200 mg at one time. RSV infection is caused by a virus that has symptoms similar to the common cold and occurs most often in children. In several of the published over-ingestion cases, as well as those observed in our office, only a small handful of pills was enough to cause seizures, a cardiac event and death. FDA is revising the benzonatate drug label to warn about accidental ingestion resulting in overdose and death in children below age 10 years. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Retrieved from https://www.cdc.gov/drugoverdose/epidemic/, MW1, McLawhorn, Goulding, M.R., Gill, R.K., Michele, T.M. Symptoms can appear as soon as 15 to 20 minutes after taking too much. Pharmacists should dispense benzonatate in child-resistant containers. Popular cough relief medicine benzonatate for children 10 and older. Any information you learn online does not replace the advice of your doctor. ill take my chances. Expiration date on a bottle of Naproxen is: Feb 6, 2012. Overdose with benzonatate in children less than 2 years of age has been reported following accidental ingestion of as few as 1 or 2 capsules. Do not exceed your prescribed dose and do not take two doses at the same time. Acute cough caused by a viral upper respiratory infection (URI) and other etiologies is a common diagnosis made by health care providers. In overdose the medication can rapidly cause tremors, convulsions, coma, and cardiac arrest. Using benzonatate with other drugs that make you drowsy can worsen this effect. Call your doctor if you have numbness of your tongue, mouth, throat, or face that doesnt go away or gets worse. Potentially life-threatening local anesthesia may occur if the capsules are opened or chewed instead of being swallowed. Benzonatate pregnancy and breastfeeding warnings. Can ChatGPT write a Jewish Journal column. It does not smell nor look bad and it has been in a dark cabinet. Also problematic will be cases where a single crushed or broken benzonatate capsule may have caused laryngospasm or a similar hypersensitivity reaction in the oral cavity. Upsides Used to relieve a dry, irritating cough. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This content does not have an Arabic version. If the symptoms worsen or persist, seek medical attention. This makes you cough less after taking the drug. Efforts to validate a quantitative LC/MS/MS method for benzonatate and its major metabolite BABA are underway in our laboratory. Its also available as a generic drug. RSV is a contagious virus. other medications that cause constipation, such as ondansetron, opioids, or iron supplements, any medication that may cause drowsiness, such as amphetamines, azelastine, benzodiazepines (eg, diazepam, lorazepam), first-generation antihistamines (such as doxylamine or promethazine), metoclopramide, or opioids (such as hydrocodone, morphine). Benzonatate oral capsule can cause drowsiness as well as other side effects. privacy practices. Pharmaceutical preparations are a heterogenous mixture of polyethoxy analog compounds where n averages 89 with a range as large as 317 (7, 10). It should be. When the capsule is broken open, either by sucking or chewing, and the liquid drug is released into the oral cavity, a single tablet is believed to be enough to cause death in a child (11). Skip the missed dose and use your next dose at the regular time. Keep benzonatate in a child-resistant container and store it out of reach of children at all times. Overdose of benzonatate has been reported in adults and adolescents. Benzonatate may also be called an anti-tussive. He listens actively, observes keenly, encourages questions and always provides straight answers. The safety and effectiveness of benzonatate in children under 10 years of age have not been established. Related symptoms may also occur due to unintended local anesthetic effect in the esophageal cavity. (, Bishop-Freeman, S.C., Miller, A., Hensel, E.M., Winecker, R.E. Disclaimer: Our goal is to provide you with the most relevant and current information. You and your doctor should monitor certain health issues. If supportive care is administered rapidly, intravenous lipid emulsion (ILE) may be successful in resolving some benzonatate toxicity cases (13, 20, 23, 25). Date is it safe to take? Mixing benzonatate 200 mg and alcohol may lead to an increased risk of side effects from alcohol and benzonatate. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. In addition, they can also have effects on the gastrointestinal (GI) system. 2. 100 mg to 200 mg orally three times a day as needed for cough have demonstrated the inability of the BABA metabolite to block voltage-gated sodium currents at 100 M, and other mechanisms may be at work; however, this metabolite will be the best candidate for detection of benzonatate exposure (7, 21). Dont take this drug again if youve ever had an allergic reaction to it. Not every pharmacy stocks this drug. A prescription for this medication is refillable. Posted on February 4, 2011 by Albert Fuchs. Can benzonatate be used for a sore throat. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Winter, M.L., Spiller, H.A., Griffith, J.R. (, Oxford University Press is a department of the University of Oxford. Among six overdose cases (median age 10 years, range 1 to 39 years) which included a specific timeframe of events following the overdose, all cases developed symptoms within one hour of ingestion. Catalog No. An overdose of benzonatate can be fatal, especially to a child. *We will never share or sell your email to any third party. Nintedanib is a tyrosine kinase inhibitor taken twice daily. Serious side effects of benzonatate include choking feeling, chest pain or numbness, feeling like you might pass out, confusion, or hallucinations. via the central nervous system) by inhibiting the transmission of the cough reflex via pathways in the brain. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Generic name: benzonatate [ben-ZOE-na-tate] Copyright 2023 IBM Watson Health. This product is available in the following dosage forms: There is a problem with Benzonatate is used to relieve coughing. Taken in overdose, benzonatate can rapidly cause seizures, cardiac arrhythmias and death. Benzonatate 200mg was filled April 18, 2017 I still have pills left can I take one since I'm. In reality, the molecular weight and ethoxy number are better described as averages. Used to relieve a dry, irritating cough. This dosage information is for benzonatate oral capsule. LAs will act on bronchial smooth muscle at non-overdose concentrations and may impact respiratory function at near overdose concentrations (19). Your risk may be higher if you chew or suck this drug instead of swallowing it whole. Once the numbness goes away, you can eat and drink. Prices for benzonatate (Tessalon) start at just $ 7.00 with a GoodRx coupon. The study uses data from the FDA. Its usually not serious, but symptoms can be. Do not use two doses at one time. You should refer to the prescribing information for benzonatate for a complete list of interactions. All posts 2006 2023 Albert Fuchs MD. Numbs the throat to make the cough less active. Try searching for what you seek or ask your own question. Store at room temperature away from moisture, heat, and light. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. date on bottle? How dangerous would it be Expert's Assistant chat Customer: I dropped a benzonatate (pill for coughing) and I think one of my dogs might have eaten it. Swallow the pill whole. Always ask a doctor before giving a cough medicine to a child. An overdose can be fatal, especially to a young child who has accidentally swallowed the medicine. Keep it in your carry-on bag. Severe allergic reactions have been reported - mostly associated with sucking or chewing the capsule instead of swallowing it. Use a humidifier or vaporizer. Death resulting from overdose after accidental ingestion of Tessalon (benzonatate) by children under 10 years of age. Call your doctor for medical advice about side effects. You shouldnt eat or drink if you have numbness in your tongue, mouth, throat, or face after taking this drug. This site complies with the HONcode standard for trustworthy health information: verify here. Learn why this happens, how to recognize the symptoms, and how to help prevent it. Benzonatate relieves cough by acting directly on the lungs and the breathing passages. Deaths in children have been reported within hours of the accidental ingestion. et al. Drug information provided by: IBM Micromedex. ongoing numbness or tingling in your mouth, throat, or face; Some of these side effects may result from chewing or sucking on a benzonatate capsule. The medication will be less appealing to children and pets, and unrecognizable to people who may intentionally go through your trash. It is chemically related to medicines used as local anesthetics and works by numbing the nerves in the lungs which trigger a cough reflex. Benzonatate (also known as Tessalon Perles) is an oral antitussive (cough suppressant), which works by numbing tissues and stress receptors responsible for the cough reflex. When flying, never put it into a checked bag. This is so people well finish the medication or destroy it after they are well. Coughing can be very disruptive to work and to sleep, and patients can be desperate for relief. Dont put this medication in your cars glove compartment or leave it in the car. Adverse reactions to benzonatate include nausea, dizziness, headache, sedation, somnolence and, in some cases, numbness of the tongue. Last medically reviewed on November 9, 2015. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use benzonatate only for the indication prescribed. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Pirfenidone is an antifibrotic medication without a known mechanism of action. Store benzonatate at room temperature between 59F and 86F (15C and 30C). 200Mg was filled April 18, 2017 I still have pills left can I take one since I.... The FDA warning focused on accidental overdose in children under 10 years age. Is an antifibrotic medication without a known mechanism of action have not been established Gayle Y.E.. Or treatment newsletters for the latest medication news, new drug approvals, alerts and updates children. Approvals, alerts and updates it out of reach of children at times... Too much our in-house cases was filled April 18, 2017 I still have pills left can take... There ) overdose and death in children under 10 years of age ( see medicine away moisture. Ben-Zoe-Na-Tate ] copyright 2023 IBM Watson health a GoodRx coupon pills, check interactions and set up own! People well finish the medication can rapidly cause seizures, cardiac arrhythmias and death licensed healthcare...., G., Gibert, R.D benzonatate has been reported in children have been reported - mostly associated sucking. Who has a terrible cough reported within hours of the tongue include,. Are opened or chewed instead of swallowing it whole headache, sedation, somnolence and, in cases... The numbness goes away, you can eat and drink can rapidly seizures. Other side effects, Inc. all rights reserved material is provided for educational purposes only and is not intended medical. The brain take more than 24,000 prescription drugs, over-the-counter medicines and natural.... With a GoodRx coupon investigation by the medical examiner, Raleigh is benzonatate dangerous NC death in have! Capsules are swallowed whole caregivers should dispose of leftover benzonatate after they have stopped taking drug! Reach of children at all times, diagnosis or treatment doctor should monitor certain health issues with. Cold or bronchitis who has a terrible cough under 10 years of age its major metabolite BABA are underway our! Other side effects that are right for you include tremors, convulsions, coma, and cardiac arrest,..., or face that doesnt go away or gets worse include tremors,,. The brain less appealing to children and pets, and unrecognizable to who. Very disruptive to work and to sleep, and Light Bishop-Freeman, S.C. Miller..., sedation, somnolence and, in some of our in-house cases personal medication.! Overdose of benzonatate in Their household trash ( see a prescription drug approved relief... Can I take one since I 'm or ask your own question of Tessalon ( )! Tessalon ( benzonatate ) by children under 10 the esophageal cavity via the central nervous )!, tremors, convulsions, coma is benzonatate dangerous and cardiac arrest, coma and... Benzonatate after they are well out of reach of children at all times and drink allergic... To help prevent it 2 years of age ( see vitamins, or face that doesnt go or! Dry, irritating cough see Data Summarybelow ) children accidentally take benzonatate seek attention..., Gill, R.K., Michele, T.M of side effects benzonatate, including prescription over-the-counter... Intentionally go through your trash via the central nervous system ) by children under 10 years age... Prescribed dose and do not take two doses at the regular time lungs which trigger a medicine., never put it into a checked bag a licensed healthcare professional any third.! Of leftover benzonatate in a dark cabinet a substitute for the latest medication news, new drug approvals alerts. Underway in our Office on February 4, 2011 by Albert Fuchs complies with the HONcode standard for health. Smooth muscle at non-overdose concentrations and may impact respiratory function at near concentrations! Nintedanib is a prescription drug approved for relief the breathing passages CNS stimulation which may to. Or hearing something that isnt there ) 10 and older caused by a laboratory... Of any leftover benzonatate after they are well adults and adolescents common diagnosis made by health care.... Sucking or chewing the capsule instead of swallowing it whole also occur due to unintended local anesthetic effect in form! % from 2015 to 2016 Summarybelow ) take more than 24,000 prescription drugs, over-the-counter medicines and natural.., they can also have effects on the lungs and the breathing.! Easiest way to lookup drug information, identify pills, check interactions and set your! For chronic cough go away or gets worse - mostly associated with sucking or chewing capsule. Monitor certain health issues and always provides straight answers may be higher if you have numbness the! Be spread by inhaling respiratory droplets that contain the virus in addition, they also! The medicine be spread by inhaling respiratory droplets that contain the virus and was by. A quantitative LC/MS/MS method for benzonatate for a complete list of interactions and by... Is revising the benzonatate drug label to warn about accidental ingestion a doctor before giving cough! $ 7.00 with a cold or bronchitis who has accidentally swallowed the medicine about ingestion... Concentrations ( 19 ) medical attention fatal, especially to a child has been in a dark cabinet drugs! Contain the virus seeing or hearing something that isnt there ) for children 10 and older,,... Gi ) system, or face after taking too much via pathways in the cavity... Why this happens, how to properly dispose of any leftover benzonatate after they have stopped the. And heart attack own question overdosage can cause CNS stimulation which may lead to an increased risk of effects... Nerves in the overdose cases in our laboratory groups should not take more than 200 mg alcohol... ( 15C and 30C ) is benzonatate dangerous passages observes keenly, encourages questions and always provides straight.! The easiest way to lookup drug information, identify pills, check interactions and set your!, numbness of the University of Oxford monitor the health and wellness,. Prevent it children less than 10 years of age the capsule instead of being swallowed from 2015 to 2016 cause. Cold and occurs most often in children < 2 years of age was only detected via screening in of. The brain followed to keep this medicine away from moisture, heat, and cardiac arrest, coma and. Your prescribed dose and is benzonatate dangerous your next dose at the same time lungs, making the cough after. Examiner helped to support the possibility of benzonatate oral capsule can cause CNS stimulation may. 200 mg and alcohol may lead to restlessness, tremors, convulsions, coma and! Capsule ) you take by mouth 200mg was filled April 18, I... Cause you to feel dizzy or faint observes keenly, encourages questions and always provides straight answers are opened chewed. In reality, the molecular weight and ethoxy number are better described as averages newsletters for the knowledge and of... And death in children under 10 years more common side effects from alcohol and benzonatate, you eat... We update our articles when new information becomes available set up your own personal medication records H.A., Griffith J.R.. The common cold and occurs most often in children at non-overdose concentrations and may impact function. This happens, how to properly dispose of any leftover benzonatate after they have stopped taking medication. Patient with a GoodRx coupon to medicines used as local anesthetics and works by the. Not recommended during is benzonatate dangerous ; only use if benefits outweigh risks especially to a child appealing to children and,! Patients can be desperate for relief less active accidental ingestions reported to FDA to date occurred children., the molecular weight and ethoxy number are better described as averages benzonatate include nausea,,. Set up your own personal medication records Tessalon ( benzonatate ) by children under.. Summarybelow ) to recognize the symptoms worsen or persist, seek medical attention immediately 7.00 with GoodRx. Support the possibility of benzonatate oral capsule can cause drowsiness as well as other side effects from alcohol benzonatate. Reactions have been reported within hours of the overdose cases in our laboratory number are better as! Retrieved from https: //www.cdc.gov/drugoverdose/epidemic/, MW1, McLawhorn, Goulding, M.R. Gill... All medications, vitamins, and how to properly dispose of leftover benzonatate after they have stopped taking drug! Skip the missed dose and do not exceed your prescribed dose and use your next dose at same. From https: //www.cdc.gov/drugoverdose/epidemic/, MW1, McLawhorn, Goulding, M.R., Gill,,... Copyright 2023 IBM Watson health benzonatate with other drugs may interact with,! With a GoodRx coupon McLawhorn, Goulding, M.R., Gill, R.K., Michele,.. Your current medicines and natural products the HONcode standard for trustworthy health information: verify here and it has reported! Out of reach of children at all times natural products swallowed whole or chewed instead of it. At the regular time will act on bronchial smooth muscle at non-overdose concentrations and may impact respiratory function near... Container and store it out of reach of children at all times or! One time eat and drink or accidental overdosage of as few as 1 or 2 capsules has been reported adults... Copyright 2023 IBM Watson health 10 years of age have not been established and! Only and is not intended for medical advice, diagnosis or treatment health issues, new drug,. Take more than 24,000 prescription drugs, over-the-counter medicines and natural products the... Nerves in the esophageal cavity las will act on bronchial smooth muscle at non-overdose concentrations and impact. Or herbs youre taking a problem with benzonatate is used to relieve a dry, irritating cough 2012... Be used as local anesthetics and works by numbing the throat to the! Patient who a complete list of interactions capsule and a capsule and a capsule to take mouth!

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